Cells4Thought: using iPSCs for neurodevelopmental health
The prevalence of neurodevelopmental disorders (NDDs), including cognitive impairments, is increasing worldwide with great impact on daily life quality. There is evidence that exposure to chemicals may contribute to the incidence of NDD. However, a causal link is lacking. Towards this goal, a human-relevant in vitro model system mimicking parts of brain development, such as neuronal network functioning, could be used for mechanistic research on how gene-environment interactions contribute to the development of NDD. This is going to be studied in the project Cells4Thought, using induced pluripotent stem cells form different individuals to study the effect of chemicals on neuronal differentiation.
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InnovationPolicyBeginner
TPI.tv: improving science through animal-free innovations and research
Introducing TPI.tv : a video platform by experts striving to improve science through animal-free innovations and research.
TPI.tv videos
Five simple tricks for making your own video for TPI.tv
This video shows you how to make a video yourself. It's really not that difficult! See also the submission page (https://tpi.tv/submit-a-video) for additional information.
Projects and initiatives
HealthToxicologyIn vitro
RISKHUNT3R project – interview by TOXstreams
Many studies are focused on finding the next best tool or test to assess the risk associated with chemical exposure. That is all well and good, but even the perfect assay needs to be accepted by regulators before seeing the light of the day. And how do we do that? The guests in this webinar have some ideas on that as principal investigators of the EU project RISK HUNT3R. Prof. Bob van de Water, Dr Mirjam Luijten and Dr Andrew White explain what RISK HUNT3R is doing, what next generation risk assessment means and why it is so important. Click on the link in the video to watch the whole interview.
Expert interviews
HealthToxicology
Ecotoxicology explained - interview by TOXstreams
Toxicology is a complicated area where you have to figure out if a chemical is safe for the entire human population? Well, some researchers in this field go even beyond, and instead of studying the safety of substances on “just” people, they focus on any living being on the whole planet. In this TOXstreams interview ecotoxicologists Dr Adam Lillicrap from the Norwegian Institute for Water Research and Dr Kristin Schirmer from the Eawag Science and Technology and co-founder of aQuaTox Solutions GmbH Solutions will explain what and how they do this. Click on the link in the video to watch the whole interview.