Stem cell derived Vessels-on-Chip to study brain disorders
Dennis Nahon is a PhD candidate in the Department of Anatomy and Embryology at the Leiden University Medical Center. In his research, under supervision of Dr. Valeria Orlova and Prof. Dr. Christine Mummery, he aims to mimic a blood vessel in the brain by combining different stem cell derived cell types, in a 3D Vessel-on-Chip model. Here, an example of these in vitro blood vessels is shown in which certain brain cells known as astrocytes (in white) interact with the blood vessels (in red). This model paves the way for investigating brain vessels outside the human body, while reducing the need for animal models.
New
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Projects and initiatives
HealthInnovationPolicy
EURL ECVAM
The EU Reference Laboratory for alternatives to animal testing (EURL ECVAM) promotes and facilitates the use of non-animal methods in testing and research. It validates, disseminates and shares knowledge on the 3Rs (Replacement, Reduction and Refinement of animal experiments). In this video, Raffaella Corvi explains what EURL ECVAM does in the field of safety testing of chemicals while reducing laboratory animal testing.
Watch the accessible version of the video here (https://audiovisual.ec.europa.eu/en/video/I-230374).
©European Union, 2021
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TPI.tv videos
Five simple tricks for making your own video for TPI.tv
This video shows you how to make a video yourself. It's really not that difficult! See also the submission page (https://tpi.tv/submit-a-video) for additional information.
![Helpathon #11 – Can you help Terry?](https://img.tradecast.eu/iYLA8UnHUeT8v3WmDQaCkWjitztH3E3AFi1plpfe5nw/rt:fit/s:320:0:1/gravity:ce/aHR0cHM6Ly90cGkudHYvY2RuL2N1c3RvbV90aHVtYm5haWxzLzE1ODEyNGUwLWNhNzktNGZmMS1hMjkwLTMzOTM4NWZkYTBjMy9jdXN0b20tdGh1bWJuYWlsLTEyODB4NzIwLmpwZw.jpg)
Questions
HelpathonsHealth
Helpathon #11 – Can you help Terry?
Terry Vrijenhoek (UMC Utrecht) is a geneticist and explores the societal impact of gene therapy. In this Helpathon the focus is on Alzheimers, for which there is no cure but there is a promising RNA-based therapy in the pipeline. Can you help Terry with designing scenarios for responsible development for gene therapy for Alzheimer disease in terms of benefits, risks, budgets and animal models? More information can be found here (https://www.helpathonhotel.org/coming-up).
![Helpathon #11 – Can you help Francesca?](https://img.tradecast.eu/T0BL9KKAvyFepGmvxSrcpzLYZkUOxsP4rjeqLFkKB8A/rt:fit/s:320:0:1/gravity:ce/aHR0cHM6Ly90cGkudHYvY2RuL2N1c3RvbV90aHVtYm5haWxzLzNhZjNkYzFlLTU0YTItNDJlYi05YzViLTNhNWMwNGI3YTc4Ny9jdXN0b20tdGh1bWJuYWlsLTEyODB4NzIwLmpwZw.jpg)
Questions
HelpathonsHealth
Helpathon #11 – Can you help Francesca?
Francesca Stillitano (UMC Utrecht) is a geneticist and an Assistant Professor at the Department of Cardiology. Francesca is currently working with mice models and with human tissue-based in vitro models to develop and test new gene therapies for a rare cardiomyopathy. Can you help Francesca with developing gene therapies for curing inherited cardiomyopathies without the use of animal models? More information can be found here (https://www.helpathonhotel.org/coming-up).