An in vitro simulator for ventricular assist devices

02:453 years ago

Despite the positive outcomes of ventricular assist device (VAD) therapy, there are still some adverse events, such as suction, caused by the mismatch of the preload of the left ventricle and the flow of the pump. Ventricular suction can be due to multiple underlying pathophysiological conditions. However, the medical management of such patients is still not well defined. In order to analyse the potential of different therapeutic interventions to mitigate suction in different pathophysiological conditions, a suction module is embedded in a cardiovascular hybrid (hydraulic-computational) simulator. The suction module mimics the ventricular apex and its connection with a HeartWare HVAD system (Medtronic). With such a set-up, the medical management of different pathophysiological conditions can be evaluated, without the use of animals.

Also watch the video on the cardiovascular simulator used for this research: https://tpi.tv/watch/76

Contact: https://www.linkedin.com/in/maria-rocchi-9aa7b4162/

Related

TPI.tv: improving science through animal-free innovations and research
TPI.tv videos
InnovationPolicyBeginner

TPI.tv: improving science through animal-free innovations and research

Introducing TPI.tv : a video platform by experts striving to improve science through animal-free innovations and research.
01:263 years ago
Five simple tricks for making your own video for TPI.tv
TPI.tv videos

Five simple tricks for making your own video for TPI.tv

This video shows you how to make a video yourself. It's really not that difficult! See also the submission page (https://tpi.tv/submit-a-video) for additional information.
01:234 years ago
RISKHUNT3R project – interview by TOXstreams
Projects and initiatives
HealthToxicologyIn vitro

RISKHUNT3R project – interview by TOXstreams

Many studies are focused on finding the next best tool or test to assess the risk associated with chemical exposure. That is all well and good, but even the perfect assay needs to be accepted by regulators before seeing the light of the day. And how do we do that? The guests in this webinar have some ideas on that as principal investigators of the EU project RISK HUNT3R. Prof. Bob van de Water, Dr Mirjam Luijten and Dr Andrew White explain what RISK HUNT3R is doing, what next generation risk assessment means and why it is so important. Click on the link in the video to watch the whole interview.
00:2130 hours ago
Ecotoxicology explained - interview by TOXstreams
Expert interviews
HealthToxicology

Ecotoxicology explained - interview by TOXstreams

Toxicology is a complicated area where you have to figure out if a chemical is safe for the entire human population? Well, some researchers in this field go even beyond, and instead of studying the safety of substances on “just” people, they focus on any living being on the whole planet. In this TOXstreams interview ecotoxicologists Dr Adam Lillicrap from the Norwegian Institute for Water Research and Dr Kristin Schirmer from the Eawag Science and Technology and co-founder of aQuaTox Solutions GmbH Solutions will explain what and how they do this. Click on the link in the video to watch the whole interview.
00:2130 hours ago